2000.9−2004.7 山东师范大学，学士学位

2004.9−2009.7 中国农业大学，博士学位

2009.7−2013.7 中国科学院微生物研究所，博士后

2013.9−2017.9 美国德克萨斯大学休斯顿健康科学中心，博士后

2017.12-2019.12 中国农业科学院生物技术研究所，助理研究员

2020.1至今 中国农业科学院生物技术研究所，副研究员

岳群

博士、副研究员

研究中心 农业微生物学研究中心

创新团队 微生物智能设计与合成创新团队

课题组 徐玉泉课题组

yuequn@caas.cn

学习工作经历

2000.9−2004.7 山东师范大学，学士学位

2004.9−2009.7 中国农业大学，博士学位

2009.7−2013.7 中国科学院微生物研究所，博士后

2013.9−2017.9 美国德克萨斯大学休斯顿健康科学中心，博士后

2017.12-2019.12 中国农业科学院生物技术研究所，助理研究员

2020.1至今 中国农业科学院生物技术研究所，副研究员

主要研究领域与成果

主要从事棘白菌素、环孢菌素等活性天然产物的生物合成与组合生物合成、基于真菌操纵子结构的多基因高效可控表达新方法的开发与应用研究。
主持国家自然科学基金项目2项、中国博士后科学基金面上项目1项，参加国内外研究项目6项；发表SCI论文20多篇，申请国家发明专利7项，其中授权6项，申请PCT专利1项；2017年入选中国农业科学院“青年英才计划”D类人才。

主要论著

1.Yue, Q., Li, Y., Chen, L., Zhang, X., Liu, X., An, Z., Bills, G.F., 2018. Genomics-driven discovery of a novel self-resistance mechanism in the echinocandin-producing fungus Pezicula radicicola, Environmental Microbiology 20, 3154-3167. (IF = 4.974)

2.Li, Y., Lan, N., Xu, L.*, Yue, Q.*, 2018. Biosynthesis of pneumocandin lipopeptides and perspectives for its production and related echinocandins, Applied Microbiology and Biotechnology 102, 9881-9891. (IF = 3.34)

3.Yue, Q.#, Chen, L.#, Li, Y.#, Bills, G., Zhang, X., Xiang, M., Li, S., Che, Y., Wang, C., Niu, X., An, Z., Liu, X., 2015. Functional operons in secondary metabolic gene clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes). mBio 6, e00703-15. (IF = 6.975)

4.Yue, Q.#, Chen, L.#, Zhang, X., Li, K., Sun, J., Liu, X., An, Z., Bills, G., 2015. Evolution of chemical diversity in the echinocandin lipopeptide antifungal metabolites. Eukaryotic Cell 14, 698-718. (IF = 2.946)

5.Liu R.#, Khan R.A.A.#, Yue Q.#, Jiao Y., Yang Y., Li Y., Xie B., 2020. Discovery of a new antifungal lipopeptaibol from Purpureocillium lilacinum using MALDI-TOF-IMS. Biochemical and Biophysical Research Communications 527, 689-695. (IF = 3.34)

6.Zhang L., Yue Q., Wang C., Xu Y., Molnár I., 2020. Secondary metabolites from hypocrealean entomopathogenic fungi: genomics as a tool to elucidate the encoded parvome. Natural Product Reports doi: 10.1039/d0np00007h. (IF = 11.872)

7.Li, Y., Yue, Q., Jayanetti, D.R., Swenson, D.C., Bartholomeusz, G.A., An, Z., Gloer, J.B. and Bills, G.F., 2017. Anti-Cryptococcus phenalenones and cyclic tetrapeptides from Auxarthron pseudauxarthron. Journal of Natural Products DOI: 10.1021/acs.jnatprod.7b00341. (IF = 3.662)

8.Li, Y., Yue, Q., Krausert, N.M., An, Z., Gloer, J.B., Bills, G.F., 2016. Emestrins: anti-Cryptococcus epipolythiodioxopiperazines from Podospora australis. Journal of Natural Products 79: 2357-2363. (IF = 3.662)

9.Lan, N., Yue, Q., An, Z., Bills, G., 2020. Apc.LaeA and Apc.VeA of the velvet complex govern secondary metabolism and morphological development in the echinocandin-producing fungus Aspergillus pachycristatus. Journal of Industrial Microbiology & Biotechnology 47:155-168. (IF = 2.993)

10.Kuhnert, E., Li, Y., Lan, N., Yue, Q., Chen, L., Cox, R.J., An, Z., Yokoyama, K., Bills, G.F., 2018. Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases. Environmental Microbiology 20, 3325-3342. (IF = 4.974)

11.Chen, L., Li, Y., Yue, Q., Loksztejn, A., Yokoyama, K., Felix, E.A., Liu, X., Zhang, N., An, Z., Bills, G.F., 2016. Engineering of new pneumocandin side-chain analogues from Glarea lozoyensis by mutasynthesis and evaluation of their antifungal activity. ACS Chemical Biology 11, 2724-2733. (IF = 5.09)

12.Xie, L., Zhang, L., Bai, J., Yue, Q., Zhang, M., Li, J., Wang, C., Xu, Y., 2019. Methylglucosylation of phenolic compounds by fungal glycosyltransferase- methyltransferase functional modules. Journal of Agricultural and Food Chemistry 67, 8573-8580. (IF = 3.571)

13.Wingfield, B.D., Bills, G.F., Dong, Y., Huang, W., Nel, W.J., Swalarsk-Parry, B.S., Vaghefi, N., Wilken, P.M., An, Z., de Beer, Z.W., De Vos, L., Chen, L., Duong, T.A., Gao, Y., Hammerbacher, A., Kikkert, J.R., Li, Y., Li, H., Li, K., Li, Q., Liu, X., Ma, X., Naidoo, K., Pethybridge, S.J., Sun, J., Steenkamp, E.T., van der Nest, M.A., van Wyk, S., Wingfield, M.J., Xiong, C., Yue, Q., Zhang, X., 2018. IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata. IMA Fungus 9, 199-223. (IF = 4.308)

主要专利

1.参与肺囊康定合成的蛋白glpks4及其编码基因；授权号：ZL201210202161.X，授权公告日：2016.01.20。

2.肺囊康定B0合成相关蛋白glpks3及其编码基因；授权号：ZL201310056488.5，授权公告日：2016.03.23。

3.参与肺囊康定合成的蛋白glnrps4及其编码基因；授权号：ZL201210202632.7，授权公告日：2016.09.07。

4.一种以真菌操纵子为基础的外源基因定点定量定时表达系统；申请号：201911072118.4，申请公告日：2020.05.01。

5.一种内源搭载的外源基因高效可控表达系统；PCT申请号：PCT/CN2020/096010。